Drug interactions
Silodosin + Sotalol
Severity: Minor
Silodosin and Sotalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Silodosin can cause orthostatic hypotension and dizziness, and sotalol adds beta-blocking hypotensive and bradycardic effects. Hypotension and dizziness are more likely, which may be harmful in patients on sotalol who are prone to arrhythmias.
What this interaction means in plain words
Silodosin and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Silodosin belongs to Genitourinary; Sotalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-1 adrenergic blockade and beta-adrenergic blockade.
What to do
Monitor standing blood pressure and heart rate when starting or adjusting either drug. Reduce the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Silodosin with Sotalol?
MediHelp rates the interaction as minor. Silodosin and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Silodosin can cause orthostatic hypotension and dizziness, and sotalol adds beta-blocking hypotensive and bradycardic effects. Hypotension and dizziness are more likely, which may be harmful in patients on sotalol who are prone to arrhythmias.
How serious is the interaction between Silodosin and Sotalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor standing blood pressure and heart rate when starting or adjusting either drug. Reduce the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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