Drug interactions
Silodosin + Stiripentol
Severity: Moderate
Silodosin and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol may inhibit P-glycoprotein and raise silodosin concentrations. This may increase dizziness and orthostatic hypotension.
What this interaction means in plain words
Silodosin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Silodosin belongs to Genitourinary; Stiripentol belongs to Central Nervous System.
Why it happens
Inhibition of P-glycoprotein efflux of silodosin, with possible CYP3A4 effects.
What to do
Monitor blood pressure and orthostatic symptoms, and reduce the silodosin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Silodosin with Stiripentol?
MediHelp rates the interaction as moderate. Silodosin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol may inhibit P-glycoprotein and raise silodosin concentrations. This may increase dizziness and orthostatic hypotension.
How serious is the interaction between Silodosin and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and reduce the silodosin dose if adverse effects occur.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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