Drug interactions
Silodosin + Trazodone
Severity: Moderate
Silodosin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has alpha-1 adrenergic blocking activity and can cause orthostatic hypotension, which may add to the effect of silodosin. The legacy suggestion of a P-gp mediated change in silodosin levels is not well established.
What this interaction means in plain words
Silodosin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Silodosin belongs to Genitourinary; Trazodone belongs to Central Nervous System.
Why it happens
Additive alpha-1 adrenergic antagonism by trazodone and silodosin, leading to orthostatic hypotension.
What to do
Monitor for dizziness, syncope and orthostatic blood pressure changes, especially at initiation and dose increases. Counsel patients to change position slowly and reduce a dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Silodosin and Trazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Silodosin with Trazodone?
MediHelp rates the interaction as moderate. Silodosin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has alpha-1 adrenergic blocking activity and can cause orthostatic hypotension, which may add to the effect of silodosin. The legacy suggestion of a P-gp mediated change in silodosin levels is not well established.
How serious is the interaction between Silodosin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, syncope and orthostatic blood pressure changes, especially at initiation and dose increases. Counsel patients to change position slowly and reduce a dose if symptomatic.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
