Drug interactions
Tenofovir alafenamide + Vadadustat
Severity: Minor
Tenofovir alafenamide and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP and may increase exposure to BCRP substrates. Tenofovir alafenamide absorption may rise modestly, with limited expected clinical effect.
What this interaction means in plain words
Tenofovir alafenamide and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tenofovir alafenamide belongs to Anti Virals; Vadadustat belongs to Endocrine.
Why it happens
Vadadustat inhibits intestinal BCRP efflux, increasing tenofovir alafenamide absorption.
What to do
No empiric adjustment is needed. Monitor renal function and tenofovir tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Tenofovir alafenamide with Vadadustat?
MediHelp rates the interaction as minor. Tenofovir alafenamide and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat inhibits BCRP and may increase exposure to BCRP substrates. Tenofovir alafenamide absorption may rise modestly, with limited expected clinical effect.
How serious is the interaction between Tenofovir alafenamide and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric adjustment is needed. Monitor renal function and tenofovir tolerability.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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