Drug interactions
Teriflunomide + Tucatinib
Severity: Moderate
Teriflunomide and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is metabolized mainly by CYP2C8, and teriflunomide is a weak CYP2C8 inhibitor. Exposure to tucatinib may rise modestly, increasing the risk of diarrhea and hepatotoxicity.
What this interaction means in plain words
Teriflunomide and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Teriflunomide belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Teriflunomide weakly inhibits CYP2C8, reducing the metabolism of tucatinib.
What to do
Monitor liver enzymes and bilirubin and watch for diarrhea during co-therapy. Reduce the tucatinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Teriflunomide with Tucatinib?
MediHelp rates the interaction as moderate. Teriflunomide and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is metabolized mainly by CYP2C8, and teriflunomide is a weak CYP2C8 inhibitor. Exposure to tucatinib may rise modestly, increasing the risk of diarrhea and hepatotoxicity.
How serious is the interaction between Teriflunomide and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin and watch for diarrhea during co-therapy. Reduce the tucatinib dose if toxicity develops.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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