Drug interactions
Trimipramine + Vasopressin
Severity: Moderate
Trimipramine and Vasopressin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can be associated with hyponatremia or SIADH, which may be compounded by vasopressin's antidiuretic action. Vasopressin also increases blood pressure and can cause coronary and cardiac effects relevant in patients on tricyclics.
What this interaction means in plain words
Trimipramine and Vasopressin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trimipramine belongs to Central Nervous System; Vasopressin belongs to Endocrine.
Why it happens
Additive water retention and hyponatremia risk, with possible additive cardiovascular effects.
What to do
Monitor serum sodium, fluid status and blood pressure, and ECG where cardiac disease exists. Reassess the combination if hyponatremia or arrhythmia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Vasopressin
- Carbamazepine + Vasopressin Moderate
- Clomipramine + Vasopressin Moderate
- Clozapine + Vasopressin Moderate
- Foscarnet + Vasopressin Moderate
- Haloperidol + Vasopressin Moderate
- Ibuprofen + Vasopressin Moderate
Frequently asked questions
Can I take Trimipramine with Vasopressin?
MediHelp rates the interaction as moderate. Trimipramine and Vasopressin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can be associated with hyponatremia or SIADH, which may be compounded by vasopressin's antidiuretic action. Vasopressin also increases blood pressure and can cause coronary and cardiac effects relevant in patients on tricyclics.
How serious is the interaction between Trimipramine and Vasopressin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium, fluid status and blood pressure, and ECG where cardiac disease exists. Reassess the combination if hyponatremia or arrhythmia develops.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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