藥物交互作用
Crizotinib + Lemborexant
嚴重程度: 嚴重
Crizotinib and Lemborexant: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Crizotinib is a moderate CYP3A inhibitor and can raise lemborexant exposure. This may increase somnolence, next-day impairment and other CNS effects.
用白話說明這項交互作用的意義
Crizotinib and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Lemborexant belongs to Central Nervous System.
為什麼會發生
Crizotinib inhibits CYP3A4-mediated metabolism of lemborexant.
處置方式
Avoid the combination where possible. If it is necessary, limit lemborexant to the reduced maximum dose recommended in its labeling for moderate CYP3A inhibitors and monitor for daytime sedation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Crizotinib 的其他交互作用
Lemborexant 的其他交互作用
常見問題
Can I take Crizotinib with Lemborexant?
MediHelp rates the interaction as major. Crizotinib and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib is a moderate CYP3A inhibitor and can raise lemborexant exposure. This may increase somnolence, next-day impairment and other CNS effects.
How serious is the interaction between Crizotinib and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is necessary, limit lemborexant to the reduced maximum dose recommended in its labeling for moderate CYP3A inhibitors and monitor for daytime sedation.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
