藥物交互作用
Irinotecan + Trastuzumab deruxtecan
嚴重程度: 嚴重
Irinotecan and Trastuzumab deruxtecan: major interaction.
最後更新
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摘要
Trastuzumab deruxtecan carries a topoisomerase I inhibitor payload and causes neutropenia, while irinotecan is also myelosuppressive. Combined use may add hematologic toxicity, diarrhea and infection risk.
用白話說明這項交互作用的意義
Irinotecan and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Irinotecan belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
為什麼會發生
Additive myelosuppression and gastrointestinal toxicity from two topoisomerase I inhibitor exposures.
處置方式
Avoid routine concurrent use; if combined, monitor complete blood counts frequently and reduce doses or delay treatment for neutropenia.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Irinotecan 的其他交互作用
Trastuzumab deruxtecan 的其他交互作用
常見問題
Can I take Irinotecan with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Irinotecan and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab deruxtecan carries a topoisomerase I inhibitor payload and causes neutropenia, while irinotecan is also myelosuppressive. Combined use may add hematologic toxicity, diarrhea and infection risk.
How serious is the interaction between Irinotecan and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use; if combined, monitor complete blood counts frequently and reduce doses or delay treatment for neutropenia.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
