藥物交互作用
Mavacamten + Megestrol
嚴重程度: 中度
Mavacamten and Megestrol: moderate interaction.
最後更新
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摘要
Mavacamten may lower exposure to CYP3A4-metabolized hormonal agents, and labeling warns of reduced efficacy of hormonal contraceptives. Megestrol used for appetite or cancer is not mainly a contraceptive, so the clinical impact depends on use.
用白話說明這項交互作用的意義
Mavacamten and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mavacamten belongs to Cardiovascular; Megestrol belongs to Oncology.
為什麼會發生
Mavacamten may induce CYP3A4 and increase the metabolism of progestins.
處置方式
If megestrol is used for contraception or hormonal therapy, add a nonhormonal method for the duration of mavacamten and for several months afterward. Monitor for loss of megestrol effect.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Megestrol 的其他交互作用
Mavacamten 的其他交互作用
常見問題
Can I take Mavacamten with Megestrol?
MediHelp rates the interaction as moderate. Mavacamten and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten may lower exposure to CYP3A4-metabolized hormonal agents, and labeling warns of reduced efficacy of hormonal contraceptives. Megestrol used for appetite or cancer is not mainly a contraceptive, so the clinical impact depends on use.
How serious is the interaction between Mavacamten and Megestrol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If megestrol is used for contraception or hormonal therapy, add a nonhormonal method for the duration of mavacamten and for several months afterward. Monitor for loss of megestrol effect.
What other medicines interact with Megestrol?
MediHelp also lists interactions of Megestrol with, for example, Dofetilide, Insulin degludec / insulin aspart, Insulin degludec-insulin aspart. The full list is on the Megestrol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
