Drug interactions
Avanafil + Silodosin
Severity: Major
Avanafil and Silodosin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A PDE5 inhibitor combined with an alpha-1 blocker can cause additive hypotension, dizziness and syncope. Silodosin is uroselective, but orthostatic effects are still possible.
What this interaction means in plain words
Avanafil and Silodosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avanafil belongs to Genitourinary; Silodosin belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1 blockade and PDE5 inhibition.
What to do
Start avanafil at the lowest dose only once the patient is stable on silodosin, and counsel about orthostatic symptoms. Monitor blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Avanafil with Silodosin?
MediHelp rates the interaction as major. Avanafil and Silodosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. A PDE5 inhibitor combined with an alpha-1 blocker can cause additive hypotension, dizziness and syncope. Silodosin is uroselective, but orthostatic effects are still possible.
How serious is the interaction between Avanafil and Silodosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start avanafil at the lowest dose only once the patient is stable on silodosin, and counsel about orthostatic symptoms. Monitor blood pressure.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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