Drug interactions
Chlorpromazine + Givosiran
Severity: Moderate
Chlorpromazine and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP2D6 activity, and chlorpromazine is partly metabolized by this enzyme. Chlorpromazine exposure may therefore rise, increasing sedation, hypotension, anticholinergic effects and QT risk.
What this interaction means in plain words
Chlorpromazine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran inhibits CYP2D6-mediated metabolism, which can raise chlorpromazine concentrations.
What to do
Monitor for sedation, hypotension and extrapyramidal or anticholinergic effects, and consider lowering the chlorpromazine dose. Consider an antipsychotic less dependent on CYP2D6 if problems occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Chlorpromazine with Givosiran?
MediHelp rates the interaction as moderate. Chlorpromazine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP2D6 activity, and chlorpromazine is partly metabolized by this enzyme. Chlorpromazine exposure may therefore rise, increasing sedation, hypotension, anticholinergic effects and QT risk.
How serious is the interaction between Chlorpromazine and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, hypotension and extrapyramidal or anticholinergic effects, and consider lowering the chlorpromazine dose. Consider an antipsychotic less dependent on CYP2D6 if problems occur.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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