Drug interactions
Cholecalciferol + Colesevelam
Severity: Minor
Cholecalciferol and Colesevelam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam may reduce absorption of fat-soluble vitamins, though the effect is smaller than with older resins. Long-term therapy could lower vitamin D levels.
What this interaction means in plain words
Cholecalciferol and Colesevelam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cholecalciferol belongs to Musculoskeletal; Colesevelam belongs to Endocrine.
Why it happens
Bile acid sequestration reduces absorption of fat-soluble vitamins.
What to do
Take vitamin D at least 4 hours before colesevelam and check vitamin D status if used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cholecalciferol
- Cholecalciferol + Digoxin Major
- Aluminum hydroxide + Cholecalciferol Moderate
- Calcium acetate + Cholecalciferol Moderate
- Calcium Carbonate + Cholecalciferol Moderate
- Calcium chloride + Cholecalciferol Moderate
- Calcium citrate + Cholecalciferol Moderate
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Cholecalciferol with Colesevelam?
MediHelp rates the interaction as minor. Cholecalciferol and Colesevelam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Colesevelam may reduce absorption of fat-soluble vitamins, though the effect is smaller than with older resins. Long-term therapy could lower vitamin D levels.
How serious is the interaction between Cholecalciferol and Colesevelam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take vitamin D at least 4 hours before colesevelam and check vitamin D status if used long term.
What other medicines interact with Cholecalciferol?
MediHelp also lists interactions of Cholecalciferol with, for example, Digoxin, Aluminum hydroxide, Calcium acetate. The full list is on the Cholecalciferol page.
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