Drug interactions
Cholecalciferol + Sucralfate
Severity: Moderate
Cholecalciferol and Sucralfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sucralfate contains aluminum, and vitamin D may increase aluminum absorption from the gut. With prolonged use, particularly in renal impairment, aluminum can accumulate and cause toxicity affecting bone and the nervous system.
What this interaction means in plain words
Cholecalciferol and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholecalciferol belongs to Musculoskeletal; Sucralfate belongs to Gastrointestinal Tract.
Why it happens
Vitamin D enhances intestinal absorption of aluminum, and aluminum is poorly excreted when renal function is reduced.
What to do
Avoid long-term combined use in patients with renal impairment and consider an alternative to sucralfate. If it is used, keep courses short.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholecalciferol
- Cholecalciferol + Digoxin Major
- Aluminum hydroxide + Cholecalciferol Moderate
- Calcium acetate + Cholecalciferol Moderate
- Calcium Carbonate + Cholecalciferol Moderate
- Calcium chloride + Cholecalciferol Moderate
- Calcium citrate + Cholecalciferol Moderate
Other interactions of Sucralfate
Frequently asked questions
Can I take Cholecalciferol with Sucralfate?
MediHelp rates the interaction as moderate. Cholecalciferol and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sucralfate contains aluminum, and vitamin D may increase aluminum absorption from the gut. With prolonged use, particularly in renal impairment, aluminum can accumulate and cause toxicity affecting bone and the nervous system.
How serious is the interaction between Cholecalciferol and Sucralfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term combined use in patients with renal impairment and consider an alternative to sucralfate. If it is used, keep courses short.
What other medicines interact with Cholecalciferol?
MediHelp also lists interactions of Cholecalciferol with, for example, Digoxin, Aluminum hydroxide, Calcium acetate. The full list is on the Cholecalciferol page.
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