Drug interactions
Dexmethylphenidate + Lisdexamfetamine
Severity: Moderate
Dexmethylphenidate and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are CNS stimulants and their combination produces additive sympathomimetic effects. This can raise blood pressure and heart rate and increase insomnia, anxiety and abuse potential. It is rarely intended therapy.
What this interaction means in plain words
Dexmethylphenidate and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmethylphenidate belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive catecholamine enhancement (release by amphetamine and reuptake inhibition by methylphenidate).
What to do
Avoid routine duplication of stimulants. If both are used, monitor blood pressure, heart rate and psychiatric symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicated
- Dexmethylphenidate + Linezolid Contraindicated
- Dexmethylphenidate + Phenelzine Contraindicated
- Dexmethylphenidate + Procarbazine Contraindicated
- Dexmethylphenidate + Rasagiline Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Dexmethylphenidate with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Dexmethylphenidate and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are CNS stimulants and their combination produces additive sympathomimetic effects. This can raise blood pressure and heart rate and increase insomnia, anxiety and abuse potential. It is rarely intended therapy.
How serious is the interaction between Dexmethylphenidate and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine duplication of stimulants. If both are used, monitor blood pressure, heart rate and psychiatric symptoms.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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