Drug interactions
DHEA + Silodosin
Severity: Minor
DHEA and Silodosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DHEA is not known to inhibit CYP3A4 or P-gp meaningfully, so a rise in silodosin levels is theoretical. If it occurred, orthostatic hypotension could be more likely.
What this interaction means in plain words
DHEA and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
DHEA belongs to Gastrointestinal Tract; Silodosin belongs to Genitourinary.
Why it happens
Possible weak CYP3A4 effect; not established.
What to do
No specific action is needed. Advise the patient to rise slowly and report dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of DHEA
- DHEA + Dihydroergotamine Moderate
- DHEA + Dihydroergotamine intranasal Moderate
- DHEA + Ergotamine Moderate
- DHEA + Pimozide Moderate
- DHEA + Dronedarone Minor
- DHEA + Erythromycin base Minor
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take DHEA with Silodosin?
MediHelp rates the interaction as minor. DHEA and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. DHEA is not known to inhibit CYP3A4 or P-gp meaningfully, so a rise in silodosin levels is theoretical. If it occurred, orthostatic hypotension could be more likely.
How serious is the interaction between DHEA and Silodosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Advise the patient to rise slowly and report dizziness.
What other medicines interact with DHEA?
MediHelp also lists interactions of DHEA with, for example, Dihydroergotamine, Dihydroergotamine intranasal, Ergotamine. The full list is on the DHEA page.
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