Drug interactions
Elagolix + Tenofovir alafenamide
Severity: Minor
Elagolix and Tenofovir alafenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a P-glycoprotein inhibitor and may increase absorption of tenofovir alafenamide, a P-gp substrate. The resulting rise in tenofovir exposure is likely small but could matter in patients with renal impairment.
What this interaction means in plain words
Elagolix and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
Elagolix inhibits intestinal P-gp efflux of tenofovir alafenamide.
What to do
No routine adjustment is required. Monitor renal function in patients with existing kidney disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Tenofovir alafenamide?
MediHelp rates the interaction as minor. Elagolix and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a P-glycoprotein inhibitor and may increase absorption of tenofovir alafenamide, a P-gp substrate. The resulting rise in tenofovir exposure is likely small but could matter in patients with renal impairment.
How serious is the interaction between Elagolix and Tenofovir alafenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. Monitor renal function in patients with existing kidney disease.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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