Drug interactions
Empagliflozin + Glipizide
Severity: Moderate
Empagliflozin and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin combined with glipizide raises the risk of hypoglycemia compared with the sulfonylurea alone. Labeling advises considering a lower secretagogue dose.
What this interaction means in plain words
Empagliflozin and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Glipizide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering from SGLT2 inhibition and sulfonylurea-induced insulin release.
What to do
Consider lowering the glipizide dose when adding empagliflozin. Monitor blood glucose and counsel on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Glipizide?
MediHelp rates the interaction as moderate. Empagliflozin and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin combined with glipizide raises the risk of hypoglycemia compared with the sulfonylurea alone. Labeling advises considering a lower secretagogue dose.
How serious is the interaction between Empagliflozin and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glipizide dose when adding empagliflozin. Monitor blood glucose and counsel on hypoglycemia.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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