Drug interactions
Empagliflozin + Hydrochlorothiazide
Severity: Moderate
Empagliflozin and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin adds osmotic diuresis to the thiazide effect, which can cause volume depletion, hypotension and renal function decline. Older patients and those with low baseline blood pressure are at greatest risk.
What this interaction means in plain words
Empagliflozin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive diuresis and natriuresis through different tubular mechanisms.
What to do
Assess volume status and blood pressure before starting empagliflozin and consider reducing the diuretic dose if at risk. Monitor renal function and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Empagliflozin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin adds osmotic diuresis to the thiazide effect, which can cause volume depletion, hypotension and renal function decline. Older patients and those with low baseline blood pressure are at greatest risk.
How serious is the interaction between Empagliflozin and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and blood pressure before starting empagliflozin and consider reducing the diuretic dose if at risk. Monitor renal function and electrolytes.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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