Drug interactions
Empagliflozin + Insulin degludec-insulin aspart
Severity: Moderate
Empagliflozin and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin lowers glucose independently of insulin, so adding it to insulin increases hypoglycemia risk. SGLT2 inhibitors with insulin dose reduction also carry a risk of ketoacidosis, including euglycemic cases.
What this interaction means in plain words
Empagliflozin and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Additive glucose-lowering effects through renal glucose excretion with insulin action.
What to do
Consider reducing the insulin dose when starting empagliflozin and monitor blood glucose. Avoid excessive insulin reduction and check ketones if the patient becomes unwell.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Empagliflozin and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin lowers glucose independently of insulin, so adding it to insulin increases hypoglycemia risk. SGLT2 inhibitors with insulin dose reduction also carry a risk of ketoacidosis, including euglycemic cases.
How serious is the interaction between Empagliflozin and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting empagliflozin and monitor blood glucose. Avoid excessive insulin reduction and check ketones if the patient becomes unwell.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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