Drug interactions
Empagliflozin + Metolazone
Severity: Moderate
Empagliflozin and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin has a mild diuretic effect, and with metolazone it may cause greater volume depletion, hypotension and kidney function decline. The risk is higher in older patients and those with low baseline blood pressure.
What this interaction means in plain words
Empagliflozin and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Metolazone belongs to Cardiovascular.
Why it happens
Additive natriuresis and osmotic diuresis lead to intravascular volume depletion.
What to do
Assess volume status and renal function before and after starting. Consider reducing the diuretic dose if volume depletion or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Metolazone?
MediHelp rates the interaction as moderate. Empagliflozin and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin has a mild diuretic effect, and with metolazone it may cause greater volume depletion, hypotension and kidney function decline. The risk is higher in older patients and those with low baseline blood pressure.
How serious is the interaction between Empagliflozin and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before and after starting. Consider reducing the diuretic dose if volume depletion or hypotension develops.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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