Drug interactions
Enzalutamide + Felbamate
Severity: Moderate
Enzalutamide and Felbamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate is partly metabolized by CYP3A4, and enzalutamide induces this enzyme. Felbamate levels may fall and seizure control may worsen. Enzalutamide itself carries seizure risk.
What this interaction means in plain words
Enzalutamide and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Felbamate belongs to Central Nervous System.
Why it happens
Enzalutamide induces CYP3A4, increasing felbamate metabolism.
What to do
Monitor seizure control and felbamate levels, adjusting the dose as needed. Be aware that enzalutamide lowers seizure threshold.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Enzalutamide with Felbamate?
MediHelp rates the interaction as moderate. Enzalutamide and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate is partly metabolized by CYP3A4, and enzalutamide induces this enzyme. Felbamate levels may fall and seizure control may worsen. Enzalutamide itself carries seizure risk.
How serious is the interaction between Enzalutamide and Felbamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and felbamate levels, adjusting the dose as needed. Be aware that enzalutamide lowers seizure threshold.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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