Drug interactions
Ezetimibe + Fenofibric acid
Severity: Minor
Ezetimibe and Fenofibric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibric acid, the active form of fenofibrate, may modestly raise ezetimibe exposure, and both agents increase cholesterol excretion into bile. The combination is used therapeutically, with a small theoretical increase in gallstone risk.
What this interaction means in plain words
Ezetimibe and Fenofibric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ezetimibe belongs to Cardiovascular; Fenofibric acid belongs to Cardiovascular.
Why it happens
Fibrates may modestly increase total ezetimibe levels, and both drugs affect biliary cholesterol excretion.
What to do
No routine dose adjustment is needed. Investigate for gallbladder disease if biliary symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ezetimibe
- Apalutamide + Ezetimibe Moderate
- Cholestyramine + Ezetimibe Moderate
- Cyclosporin + Ezetimibe Moderate
- Ezetimibe + Gemfibrozil Moderate
- Ezetimibe + Glecaprevir / pibrentasvir Moderate
- Ezetimibe + Letermovir Moderate
Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Frequently asked questions
Can I take Ezetimibe with Fenofibric acid?
MediHelp rates the interaction as minor. Ezetimibe and Fenofibric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibric acid, the active form of fenofibrate, may modestly raise ezetimibe exposure, and both agents increase cholesterol excretion into bile. The combination is used therapeutically, with a small theoretical increase in gallstone risk.
How serious is the interaction between Ezetimibe and Fenofibric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Investigate for gallbladder disease if biliary symptoms develop.
What other medicines interact with Ezetimibe?
MediHelp also lists interactions of Ezetimibe with, for example, Apalutamide, Cholestyramine, Cyclosporin. The full list is on the Ezetimibe page.
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