Drug interactions
Felbamate + Posaconazole
Severity: Moderate
Felbamate and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The expected interaction is unclear: felbamate is partly metabolized by CYP3A4 and 2E1, so a clinically meaningful rise with posaconazole is uncertain. Felbamate also weakly induces CYP3A4, which could lower posaconazole exposure.
What this interaction means in plain words
Felbamate and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felbamate belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Possible CYP3A4 inhibition of felbamate metabolism and weak felbamate induction; the net effect is not well established.
What to do
Monitor for felbamate adverse effects and blood counts and liver tests, and consider posaconazole levels to confirm antifungal exposure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Posaconazole?
MediHelp rates the interaction as moderate. Felbamate and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The expected interaction is unclear: felbamate is partly metabolized by CYP3A4 and 2E1, so a clinically meaningful rise with posaconazole is uncertain. Felbamate also weakly induces CYP3A4, which could lower posaconazole exposure.
How serious is the interaction between Felbamate and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for felbamate adverse effects and blood counts and liver tests, and consider posaconazole levels to confirm antifungal exposure.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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