Drug interactions
Fenofibrate + Tucatinib
Severity: Minor
Fenofibrate and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A, but fenofibrate is cleared mainly by esterase hydrolysis and glucuronidation. A clinically meaningful interaction is unlikely.
What this interaction means in plain words
Fenofibrate and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
Theoretical CYP3A inhibition with minimal relevance to fenofibric acid clearance.
What to do
No dose adjustment is needed. Monitor liver enzymes routinely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Fenofibrate with Tucatinib?
MediHelp rates the interaction as minor. Fenofibrate and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib inhibits CYP3A, but fenofibrate is cleared mainly by esterase hydrolysis and glucuronidation. A clinically meaningful interaction is unlikely.
How serious is the interaction between Fenofibrate and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor liver enzymes routinely.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
Full monographs, dosing and an interaction checker in the MediHelp app
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