Drug interactions
Maraviroc + Silodosin
Severity: Moderate
Maraviroc and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc can cause postural hypotension and dizziness, which may add to the hypotensive effect of silodosin. The risk is greatest in patients with renal impairment or other hypotensive therapy.
What this interaction means in plain words
Maraviroc and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maraviroc belongs to Anti Virals; Silodosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic effect on orthostatic blood pressure; mechanism for maraviroc is not fully defined.
What to do
Monitor orthostatic blood pressure and counsel on slow position changes. Adjust doses if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Silodosin?
MediHelp rates the interaction as moderate. Maraviroc and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc can cause postural hypotension and dizziness, which may add to the hypotensive effect of silodosin. The risk is greatest in patients with renal impairment or other hypotensive therapy.
How serious is the interaction between Maraviroc and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure and counsel on slow position changes. Adjust doses if symptomatic hypotension develops.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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