Drug interactions
Mitomycin + Tepotinib
Severity: Moderate
Mitomycin and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and can increase exposure to P-gp substrates. Mitomycin may be a P-gp substrate, so toxicity could be enhanced, though this is not well characterized.
What this interaction means in plain words
Mitomycin and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitomycin belongs to Oncology; Tepotinib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by tepotinib, potentially increasing mitomycin exposure.
What to do
Monitor for increased mitomycin toxicity, especially myelosuppression, and consider dose reduction if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Mitomycin with Tepotinib?
MediHelp rates the interaction as moderate. Mitomycin and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein and can increase exposure to P-gp substrates. Mitomycin may be a P-gp substrate, so toxicity could be enhanced, though this is not well characterized.
How serious is the interaction between Mitomycin and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased mitomycin toxicity, especially myelosuppression, and consider dose reduction if toxicity develops.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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