Drug interactions
Mitomycin + Tucatinib
Severity: Moderate
Mitomycin and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-glycoprotein and can raise exposure to P-gp substrates. Mitomycin may therefore reach higher systemic levels, increasing the risk of myelosuppression and other toxicity.
What this interaction means in plain words
Mitomycin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitomycin belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits P-gp efflux, reducing mitomycin clearance.
What to do
Monitor blood counts and toxicity closely, and consider reducing the mitomycin dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Mitomycin with Tucatinib?
MediHelp rates the interaction as moderate. Mitomycin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits P-glycoprotein and can raise exposure to P-gp substrates. Mitomycin may therefore reach higher systemic levels, increasing the risk of myelosuppression and other toxicity.
How serious is the interaction between Mitomycin and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and toxicity closely, and consider reducing the mitomycin dose if toxicity appears.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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