Drug interactions
Porfimer + Prochlorperazine
Severity: Moderate
Porfimer and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines are photosensitizing and porfimer causes marked photosensitivity after photodynamic therapy. Combining them may intensify or prolong skin phototoxic reactions.
What this interaction means in plain words
Porfimer and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Porfimer belongs to Miscellaneous; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive photosensitizing effects.
What to do
Reinforce strict light and sun protection for the period of porfimer photosensitivity. Consider an alternative to prochlorperazine during that period if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Porfimer
Frequently asked questions
Can I take Porfimer with Prochlorperazine?
MediHelp rates the interaction as moderate. Porfimer and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines are photosensitizing and porfimer causes marked photosensitivity after photodynamic therapy. Combining them may intensify or prolong skin phototoxic reactions.
How serious is the interaction between Porfimer and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reinforce strict light and sun protection for the period of porfimer photosensitivity. Consider an alternative to prochlorperazine during that period if feasible.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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