Drug interactions
Posaconazole + Silodosin
Severity: Contraindicated
Posaconazole and Silodosin: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and also inhibits P-glycoprotein, so it can markedly raise silodosin concentrations. Strong CYP3A4 inhibitors are contraindicated with silodosin because of the risk of orthostatic hypotension, dizziness and syncope.
What this interaction means in plain words
Posaconazole and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Posaconazole belongs to Anti Fungals; Silodosin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by posaconazole reduces silodosin clearance and increases its exposure.
What to do
Do not combine; choose an alternative alpha-blocker or antifungal. If antifungal therapy is unavoidable, hold silodosin for the duration of treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Silodosin?
MediHelp rates the interaction as contraindicated. Posaconazole and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole is a strong CYP3A4 inhibitor and also inhibits P-glycoprotein, so it can markedly raise silodosin concentrations. Strong CYP3A4 inhibitors are contraindicated with silodosin because of the risk of orthostatic hypotension, dizziness and syncope.
How serious is the interaction between Posaconazole and Silodosin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an alternative alpha-blocker or antifungal. If antifungal therapy is unavoidable, hold silodosin for the duration of treatment.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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