Drug interactions
Rolapitant + Talazoparib
Severity: Moderate
Rolapitant and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant inhibits BCRP and may increase talazoparib exposure. Higher levels may worsen myelosuppression such as anemia, neutropenia and thrombocytopenia.
What this interaction means in plain words
Rolapitant and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rolapitant belongs to Gastrointestinal Tract; Talazoparib belongs to Oncology.
Why it happens
Rolapitant inhibits BCRP, reducing efflux of talazoparib and increasing its systemic exposure.
What to do
Monitor blood counts and adverse reactions if coadministration cannot be avoided. Consider a different antiemetic if alternatives are suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Rolapitant with Talazoparib?
MediHelp rates the interaction as moderate. Rolapitant and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant inhibits BCRP and may increase talazoparib exposure. Higher levels may worsen myelosuppression such as anemia, neutropenia and thrombocytopenia.
How serious is the interaction between Rolapitant and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and adverse reactions if coadministration cannot be avoided. Consider a different antiemetic if alternatives are suitable.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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