Drug interactions
Ezetimibe + Fenofibrate
Severity: Minor
Ezetimibe and Fenofibrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate modestly increases ezetimibe exposure, and both drugs can increase biliary cholesterol excretion, raising the theoretical risk of cholelithiasis. The combination is commonly used for mixed dyslipidemia and is generally well tolerated.
What this interaction means in plain words
Ezetimibe and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ezetimibe belongs to Cardiovascular; Fenofibrate belongs to Cardiovascular.
Why it happens
Fibrates may modestly increase total ezetimibe levels, and both drugs affect biliary cholesterol excretion.
What to do
No dose adjustment is usually needed. Evaluate the gallbladder if biliary symptoms occur and stop fenofibrate if gallstones are found.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ezetimibe
- Apalutamide + Ezetimibe Moderate
- Cholestyramine + Ezetimibe Moderate
- Cyclosporin + Ezetimibe Moderate
- Ezetimibe + Gemfibrozil Moderate
- Ezetimibe + Glecaprevir / pibrentasvir Moderate
- Ezetimibe + Letermovir Moderate
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporin + Fenofibrate Moderate
Frequently asked questions
Can I take Ezetimibe with Fenofibrate?
MediHelp rates the interaction as minor. Ezetimibe and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate modestly increases ezetimibe exposure, and both drugs can increase biliary cholesterol excretion, raising the theoretical risk of cholelithiasis. The combination is commonly used for mixed dyslipidemia and is generally well tolerated.
How serious is the interaction between Ezetimibe and Fenofibrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Evaluate the gallbladder if biliary symptoms occur and stop fenofibrate if gallstones are found.
What other medicines interact with Ezetimibe?
MediHelp also lists interactions of Ezetimibe with, for example, Apalutamide, Cholestyramine, Cyclosporin. The full list is on the Ezetimibe page.
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