MediHelp
Drug interactions A–Z
Known drug-drug interactions with severity, mechanism and clinical management.
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
- lisinopril + sitagliptin moderate
- lisinopril + spironolactone major
- Losartan + Nitroglycerin moderate
- lovastatin + ritonavir contraindicated
- Lubiprostone + Mosapride moderate
- lurasidone + rifampin contraindicated
- lurasidone + ritonavir contraindicated
- mebendazole + metronidazole major
- meperidine + phenelzine contraindicated
- meperidine + tranylcypromine contraindicated
- metformin + proton pump inhibitor (class) moderate
- Metformin + Sulpiride moderate
- methadone + ondansetron major
- methotrexate (high-dose) + proton pump inhibitors (e.g., omeprazole) major
- Methotrexate + Nitrofurantoin moderate
- methotrexate + trimethoprim-sulfamethoxazole major
- Methylphenidate + Valproic acid moderate
- methylprednisolone + terbutaline moderate
- metoprolol + verapamil major
- metronidazole + warfarin major
- Mirogabalin + Pregabalin moderate
- Mirtazapine + Nebivolol moderate
- Mirtazapine + Sertraline moderate
- moclobemide + triptans (e.g., sumatriptan) major
- Modafinil + Sertraline moderate
- Mosapride + Prucalopride moderate
- moxifloxacin + sotalol major
- moxifloxacin + ziprasidone major
- Nalidixic Acid + Sucralfate major
- Nebivolol + Sacubitril/Valsartan moderate
- Nebivolol + Sertraline moderate
- nifedipine + verapamil moderate
- nitroglycerin + sildenafil contraindicated
- nitroglycerin + tadalafil contraindicated
- NSAID + warfarin major
- NSAIDs + warfarin major
- Olanzapine + Ondansetron moderate
- Olanzapine + Oxcarbazepine moderate
- omega-3 fatty acids (fish oil) + warfarin moderate
- Omega-3 fatty acids + Ramipril moderate
- omeprazole + warfarin moderate
- Ondansetron + Oxcarbazepine moderate
- ondansetron + voriconazole major
- opioid + tramadol major
- oxycodone + tramadol major
- pantoprazole + warfarin moderate
- paracetamol + warfarin moderate
- paroxetine + tamoxifen major
- paroxetine + thioridazine contraindicated
- penicillin + tetracycline moderate
- phenelzine + sumatriptan contraindicated
- phenelzine + tramadol contraindicated
- Phenobarbital + Theophylline moderate
- phenytoin + trimethoprim-sulfamethoxazole major
- Phylloquinone + Warfarin major
- Piperacillin + Voriconazole moderate
- Piperacillin/Tazobactam + Voriconazole moderate
- Piroxicam + Tizanidine moderate
- posaconazole + rifampin major
- posaconazole + simvastatin contraindicated
- potassium chloride + spironolactone major
- prasugrel + warfarin major
- prazosin + sildenafil major
- prednisolone + ramipril moderate
- prednisolone + salbutamol moderate
- procarbazine + sertraline major
- propafenone + ritonavir major
- Propranolol + Sulpiride moderate
- proton pump inhibitor + warfarin moderate
- quetiapine + rifampin major
- quetiapine + ritonavir major
- quinidine + ritonavir major
- ranolazine + rifampin contraindicated
- rifampin + ritonavir-boosted atazanavir contraindicated
- rifampin + rivaroxaban major
- rifampin + ticagrelor major
- rifampin + voriconazole contraindicated
- rifampin + warfarin major
- riociguat + sildenafil contraindicated
- risperidone + sertraline moderate
- ritonavir + sildenafil major
- Sacubitril/Valsartan + Torsemide moderate
- selegiline + sertraline contraindicated
- selegiline + xylometazoline contraindicated
- sirolimus + voriconazole major
- spironolactone + trimethoprim major
- spironolactone + trimethoprim-sulfamethoxazole major
- statin + warfarin moderate
- tacrolimus + voriconazole major
- Tetracycline + Zinc sulfate moderate
- Tretinoin + Urea moderate
- Trimethoprim + Warfarin moderate
- trimethoprim-sulfamethoxazole + warfarin major
Full monographs, dosing and an interaction checker in the MediHelp app
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